At the beginning of the battle in Kingdom's come, I accidentally hit Synin, which is not available. Instead, I rocketed to the upper edge of the sky and plummeted to my death. The game saved there, 3 different saves around the same time.
I was able to reload an earlier save, but quite annoying.
Stock game, only character. PC, Windows 10 Pro 64. Nvidia 2080 460.89 (12/15)